MAPK-IN-5 is a potent MAPK inhibitor with an IC50 of 1.35 µM against HeLa cells. MAPK-IN-5 inhibits HeLa cell proliferation by inducing ROS-mediated DNA damage and mitochondrial apoptosis via the MAPK pathway. MAPK-IN-5 significantly inhibits colony formation, reduces the number of live cells, suppresses cell migration, and causes cell cycle arrest in the G2/M phase in HeLa cells. MAPK-IN-5 can be used for the study of cervical cancer[1].
Molecular Weight:
594.58
CAS Number:
[2579683-39-7]
Formula:
C30H29F3N6O4
Target:
Apoptosis,Bcl-2 Family,Caspase,p38 MAPK,PARP,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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