LO-3-61, a JQ-1 (HY-13030) analog bearing a truncated fumaramide handle, is a PROTAC (proteolysis-targeting chimeras)-like BRD4 degrader. LO-3-61 degrades both the long and short isoforms of BRD4 CUL4DcAr16-dependently in cells. LO-3-61 shows selectivity for BRD3 and BRD4 degradation in MDA-MB-231 cells[1].
Molecular Weight:
677.60
Formula:
C32H30Cl2N8O3S
Target:
E1/E2/E3 Enzyme,Epigenetic Reader Domain
Application Notes:
MCE Product type: Reference compound
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