LO-3-63, a Ribociclib (HY-15777) analog bearing a truncated fumaramide handle, is a PROTAC-like CDK4/6 degrader. LO-3-63 induces CUL4DCAF16-dependent degradation of CDK4/6 in cells[1].
Molecular Weight:
643.14
Formula:
C32H35ClN10O3
Target:
CDK,E1/E2/E3 Enzyme
Application Notes:
MCE Product type: Reference compound
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