SHP2 protein degrader-3 is a SHP2 AUTAC degrader. SHP2 protein degrader-3 shows dose-dependent SHP2 degradation ability (DC50 = 3.22 µM) and anti-tumor activity (IC50 = 5.59 µM) in HeLa cells. SHP2 protein degrader-3 induces degradation through the LC3-mediated autophagy pathway, which can be inhibited by lysosome inhibitors. SHP2 protein degrader-3 induces apoptosis in various cancer cells (HeLa cells, HepG2 cells, LoVo cells, Huh-7 cells) (SHP2 Ligand : (HY-100388), LC3 Ligand: (HY-10542), Linker : (HY-128834))[1].
Molecular Weight:
1213.58
Formula:
C46H51Br2Cl2IN10O7
Target:
Apoptosis,Atg8/LC3,AUTACs,Autophagy,SHP2
Application Notes:
MCE Product type: Reference compound
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