Nrf2-IN-4 is a Nrf2 inhibitor. Nrf2-IN-4 induces ferroptosis via NRF2 inhibition. Nrf2-IN-4 disrupts cellular iron homeostasis, facilitates ferritin degradation, and ultimately triggers ferroptosis. Nrf2-IN-4 induces lysosome activation by promoting iron-dependent ROS production and lysosomal acidification. Nrf2-IN-4 demonstrates significant antitumor efficacy. Nrf2-IN-4 can be used for the study of breast cancer[1].
Molecular Weight:
426.32
CAS Number:
[2417486-06-5]
Formula:
C20H13Cl2N5S
Target:
Atg8/LC3,Ferroptosis,Keap1-Nrf2,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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