Nrf2-IN-4 (Compound PhcY) hydrobromide is a Nrf2 inhibitor. Nrf2-IN-4 hydrobromide induces ferroptosis via NRF2 inhibition. Nrf2-IN-4 hydrobromide disrupts cellular iron homeostasis, facilitates ferritin degradation, and ultimately triggers ferroptosis. Nrf2-IN-4 hydrobromide induces lysosome activation by promoting iron-dependent ROS production and lysosomal acidification. Nrf2-IN-4 hydrobromide demonstrates significant antitumor efficacy. Nrf2-IN-4 hydrobromide can be used for the study of breast cancer[1].
Molecular Weight:
507.23
Purity:
99.48
Formula:
C20H14BrCl2N5S
Target:
Atg8/LC3,Ferroptosis,Keap1-Nrf2,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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