GL64 is a selective agonist of ADGRD1 (EC50 = 3.98 µM). GL64 has low selectivity for ADGRD2, ADGRG5, ADGRG6, CELSR1, CELSR2, CELSR3, and ADGRG4 isoforms. GL64 activates ADGRD1 by mimicking the satchel sequence. GL64 regulates osteoclast maturation through the cAMP-PKA-NFATC1 pathway. GL64 effectively inhibits osteoclastogenesis and prevents bone loss both in vitro and in vivo. GL64 is useful in the study of osteoclast-related diseases[1].
Molecular Weight:
509.81
Purity:
98.80
CAS Number:
[488801-10-1]
Formula:
C27H19Cl3N2O2
Target:
Endogenous Metabolite,Nuclear Factor of activated T Cells (NFAT)
Application Notes:
MCE Product type: Reference compound
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