KI-DX-014 is a DDX21 inhibitor with an IC50 of 3.31 µM. KI-DX-014 significantly inhibits the DDX21-RNA interaction and modulates ATPase activity and biomolecular condensate formation. KI-DX-014 reduces the DDX21-dependent release of P-TEFb from the 7SK snRNP complex, inhibits P-TEFb-dependent phosphorylation of the RNA polymerase II CTD, and induces developmental defects in zebrafish embryos. KI-DX-014 can be used for cancers and neurodegenerative disorders research[1].
Molecular Weight:
330.38
Purity:
99.87
CAS Number:
[1309288-83-2]
Formula:
C17H22N4O3
Target:
ATP Synthase,DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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