TNF-alpha-IN-25 is an orally active TNF-alpha inhibitor. TNF-alpha-IN-25 shows Fluorescence Polarization (FP) assay IC50 of 103 nM in FP binding assays and L929 assay IC50 of 505 nM in cell-based assays. TNF-alpha-IN-25 inhibits paw swelling in the glucose-6-phosphate isomerase (GPI) arthritis model. TNF-alpha-IN-25 can be used for the study of arthritis[1].
Molecular Weight:
416.45
Formula:
C23H21FN6O
Target:
TNF Receptor
Application Notes:
MCE Product type: Reference compound
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