ZN-c5 is a selective and orally active estrogen receptor degrader. ZN-c5 exhibits high potency in the cellular assay (MCF-7, IC50 = 0.3 nM) and binds with high affinity to ERalpha and ERbeta (IC50 = 0.4 nM and 0.8 nM, respectively). ZN-c5 inhibits tumor growth in MCF-7 mouse xenograft model and WHIM20 xenograft model. ZN-c5 can be used for the study of breast cancer[1].
Molecular Weight:
434.48
CAS Number:
[2136606-87-4]
Formula:
C26H24F2N2O2
Target:
Estrogen Receptor/ERR
Application Notes:
MCE Product type: Reference compound
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