Mtb-IN-12 (Compound 5m) is a dual-target inhibitor that can target the CYP125 (KD: 40 nM, KI: 0.1 µM) and CYP142 (KD: 160 nM, KI: 0.05 µM) enzymes of Mycobacterium tuberculosis. Mtb-IN-12 exhibits good inhibitory activity against both drug-sensitive strains and multidrug-resistant tuberculosis strains, with low toxicity to macrophages. Mtb-IN-12 can be used in the research of anti-tuberculosis drugs[1].
Molecular Weight:
304.39
Formula:
C20H20N2O
Target:
Bacterial,Cytochrome P450
Application Notes:
MCE Product type: Reference compound
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