MI891 is a highly selective PXR antagonist (IC50 = 3.76 µM, Kd = 1.7 µM) and inverse agonist (IC50 = 6.1 µM). MI891 selectively disrupts the interaction between PXR and its coactivator SRC1. MI891 effectively inhibits Rifampicin (HY-B0272)-induced PXR activation. MI891 is useful for the study of metabolic diseases and other diseases[1].
Molecular Weight:
499.30
CAS Number:
[2530027-77-9]
Formula:
C23H14Cl2F2N6O
Target:
Cytochrome P450,Pregnane X Receptor (PXR)
Application Notes:
MCE Product type: Reference compound
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