MI1013
Catalog Number:
MCE-HY-175266
| Article Name: |
MI1013 |
| Biozol Catalog Number: |
MCE-HY-175266 |
| Supplier Catalog Number: |
HY-175266 |
| Alternative Catalog Number: |
MCE-HY-175266-1MG,MCE-HY-175266-5MG,MCE-HY-175266-10MG,MCE-HY-175266-10MMX1ML,MCE-HY-175266-25MG,MCE-HY-175266-50MG |
| Manufacturer: |
MedchemExpress |
| Category: |
Biochemikalien |
| MI1013 is a PROTAC PXR degrader (DC50 = 89 nM, Dmax = 82%). MI1013 degrades PXR in human hepatocellular carcinoma RG cells (HepaRG). MI1013 specifically and safely regulates CYP3A4 promoter activity through PXR degradation. MI1013 affects several key genes involved in sulfate conjugation (e.g., SULT1E1), bile acid synthesis (CYP7A1), gluconeogenesis (PCK1), ketone synthesis (HMGCS20), and hepatocyte proliferation (MKI67). (Pink: PXR ligand 3: HY-175267, Blue: Pomalidomide-propargyl ligand: HY-W410002, Pink + Black: PXR ligand-Linker Conjugate 1: HY-175268)[1]. |
| Molecular Weight: |
914.94 |
| Purity: |
99.10 |
| Formula: |
C42H46N10O12S |
| Target: |
Cytochrome P450,Pregnane X Receptor (PXR),PROTACs |
| Application Notes: |
MCE Product type: Reference compound |
