PIM1-IN-8 is a PIM1/p65 pathway inhibitor. PIM1-IN-8 suppresses the expression of alpha-SMA and collagen I in activated fibroblasts and blocks TGF-beta induced migration. PIM1-IN-8 alleviates pulmonary fibrosis in a Bleomycin (BLM) (HY-17565A)-induced pulmonary fibrosis mice model. PIM1-IN-8 can be used for the study of idiopathic pulmonary fibrosis (IPF)[1].
Molecular Weight:
299.32
Formula:
C17H17NO4
Target:
Interleukin Related,NF-kappaB,Pim
Application Notes:
MCE Product type: Reference compound
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