BAL-1516 is a brain-penetrant and highly selective NLRP3 inhibitor (IC50=14.2 nM). BAL-1516 significantly suppresses IL-1beta and IL-18 release in microglial neuroinflammation models (IC50=11-59 nM). BAL-1516 is promising for research of neurodegenerative diseases (e.g., Alzheimers, Parkinsons) and systemic inflammatory disorders[1].
Molecular Weight:
435.54
Formula:
C23H25N5O2S
Target:
NOD-like Receptor (NLR)
Application Notes:
MCE Product type: Reference compound
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