PROTAC c-Met degrader-6 is a potent and orally active c-Met PROTACdegrader. PROTAC c-Met degrader-6 significantly induces the degradation of the c-Met protein with DC50s of 0.52 nM and 0.45 nM in EBC-1 and Hs746T. PROTAC c-Met degrader-6 almost abrogates the migratory and invasion abilities of tumor cells and significantly induces the apoptosis and blocks the cell cycle in the G0/G1 phase. PROTAC c-Met degrader-6 can be used for the study of various cancers such as non-small cell lung cancer and stomach cancer (Pink: c-Met ligand (HY-W425461), Blue: E3 ligand (HY-14658), Black: Linker (HY-20797))[1].
Molecular Weight:
749.77
Formula:
C41H35N9O6
Target:
Apoptosis,c-Met/HGFR,PROTACs
Application Notes:
MCE Product type: Reference compound
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