DHC-286 is a molecular glue degrader targeting GSPT1. DHC-286 recruits GSPT1 to the CRL4CRBN ubiquitin ligase complex, promoting GSPT1 ubiquitination and proteasomal degradation, inducing cytotoxicity. DHC-286 is promising for research of cancers such as acute myeloid leukemia[1].
Molecular Weight:
475.42
CAS Number:
[2920443-08-7]
Formula:
C23H20F3N3O5
Target:
Molecular Glues
Application Notes:
MCE Product type: Reference compound
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