PROTAC BET Degrader-13 (Compound 34) is a TRIM21-based PROTAC (TRIMTAC) degrader targeting BET. PROTAC BET Degrader-13 significantly degrades PML-eGFP-BRD4 fusion protein with a near-complete loss of EGFP+ nuclear puncta with an EC50 of 1.4 µM[1]. Pink: BET ligand (HY-13030), Blue: E3 ligase ligand (HY-W1125585), Black: linker
Molecular Weight:
908.51
Formula:
C47H54ClN9O6S
Target:
Epigenetic Reader Domain,PROTACs
Application Notes:
MCE Product type: Reference compound
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