APY29, an ATP-competitive inhibitor, is an allosteric modulator of IRE1alpha which inhibits IRE1alpha autophosphorylation by binding to the ATP-binding pocket with IC50 of 280 nM. APY29 acts as a ligand that allosterically activates IRE1alpha adjacent RNase domain[1].
Molecular Weight:
332.36
Purity:
99.90
CAS Number:
[1216665-49-4]
Formula:
C17H16N8
Target:
IRE1
Application Notes:
MCE Product type: Reference compound
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