DeFer-2, CAS [[3058911-16-0]] Preis auf Anfrage

Product Overview

• Article Name: DeFer-2, CAS [[3058911-16-0]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-175381
• Supplier Catalog Number: HY-175381
• Alternative Catalog Number: MCE-HY-175381-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

DeFer-2 is a ferritin PROTAC degrader (Kd = 17.1 µM). DeFer-2 induces ferritin degradation, triggering caspase 3-GSDME-mediated pyroptosis in cancer cells through free iron accumulation and elevated ROS. DeFer-2 significantly inhibits tumor growth and prolongs survival in mice bearing B16F10 subcutaneous tumors. DeFer-2 can be used to study melanoma. (Pink: Oleic acid: HY-N1446, Blue: (S,R,S)-AHPC: HY-125845, Black: gamma-Aminobutyric acid: HY-N0067, Blue + Black: (S,R,S)-AHPC-C3-NH2: HY-130711)[1].

Product Properties

• Molecular Weight: 780.11
• CAS Number: [3058911-16-0]
• Formula: C44H69N5O5S
• Target: Caspase,PROTACs,Pyroptosis,Reactive Oxygen Species (ROS)

Application Notes

• Application Notes: MCE Product type: Reference compound