GNE-5472 is a potent bifunctional ERalpha PRRTAC degrader, with its E3 ligand being a pan-IAP antagonist. GNE-5472 antagonizes cIAP1/2, activating the non-classical NF-kappaB pathway, resulting in a significant upregulation of TNFalpha expression. GNE-5472 inhibits the proliferation of breast cancer cells and induces cell apoptosis. GNE-5472 can be used for the study of breast cancer[1].
