GDC-0152-acetamide is a pan-inhibitor of apoptosis protein (IAP) antagonist. GDC-0152-acetamide induces cIAP1/2 autoubiquitination and degradation, activating the non-canonical NF-kappaB pathway to promote TNF-alpha secretion and tumor cell apoptosis. GDC-0152-acetamide is promising for research of ERalpha-positive breast cancer[1].
Molecular Weight:
554.70
Formula:
C28H38N6O4S
Target:
Apoptosis,IAP
Application Notes:
MCE Product type: Reference compound
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