MRT-23227 is a molecular glue degrader that targets cereblon (CRBN). MRT-23227 forms a ternary complex with CRBN and G3BP2, activating the ubiquitin-proteasome system, leading to G3BP2 degradation. MRT-23227 has potential applications in the research of G3BP2-related cancers (such as breast and lung cancer) and neurodegenerative diseases[1].
Molecular Weight:
409.87
CAS Number:
[3050683-03-6]
Formula:
C22H20ClN3O3
Target:
Molecular Glues
Application Notes:
MCE Product type: Reference compound
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