HI042 is a FMS-like Tyrosine Kinase 3 (FLT3) inhibitor. HI042 shows IC50 values of 0.62 µM for MOLM-13, 0.33 µM for MV4-11, and 0.89 µM for OCI-AML3 cells. HI042 selectively reduces the viability of FLT3-internal tandem duplication (FLT3-|TD) mutations-positive cell lines, induces apoptosis, disrupts cell cycle progression, and diminishes the clonogenic potential. HI042 can be used for the research of acute myeloid leukemia (AML)[1].
Molecular Weight:
301.32
CAS Number:
[898168-15-5]
Formula:
C14H11N3O3S
Target:
Apoptosis,FLT3
Application Notes:
MCE Product type: Reference compound
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