Adrafinil (CRL-40028, Olmifon), prodrug of modafinil, is a mild central nervous system stimulant drug used to relieve excessive sleepiness and inattention, Adrafinil is believed to serve as an alpha-1 adrenoceptor agonist. IC50 value: Target: in vitro: in vivo: CRL 40028 antagonizes prazosin-induced hypothermia and hypomotility, prazosin antagonizes the anticonvulsant effect of CRL 40028 in the quaking mouse [1]. Adrafinil in rat serum was stable over three freeze-thaw cycles at ambient temperature for 6 h. The method had a lower limit of quantitation of 16.5 ng/ml, which offered high sensitivity for the determination of adrafinil in serum [2]. Aged beagle dogs were trained on either a size or intensity discrimination task 2 h following treatment with either 20 mg/kg of adrafinil or a placebo control. Treatment with adrafinil produced significant improvement in learning, as indicated by a decrease in both errors and trials to criterion. An effect of adrafinil on motivation may partially account for these findings, however, adrafinil did not significantly affect response latency. Adrafinil is believed to serve as an alpha-1 adrenoceptor agonist [3].
Molecular Weight:
289.35
Purity:
99.85
CAS Number:
[63547-13-7]
Formula:
C15H15NO3S
Target:
Adrenergic Receptor
Application Notes:
MCE Product type: Reference compound
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