6PGD-IN-2 is an uncompetitive 6-phosphogluconate dehydrogenase (6PGD) inhibitor with an IC50 of 5.1 µM. 6PGD-IN-2 disrupts 6PGD oligomerization in a substrate-dependent manner. 6PGD-IN-2 results in a decrease of NADPH and Ru-5-P production as well as DNA synthesis in A549 cells. 6PGD-IN-2 can used for the studies of non-small cell carcinoma and liver cancer[1].
Molecular Weight:
461.14
Formula:
C16H9BrCl2FN3OS
Target:
DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound1
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