P-gp-IN-31 is a P-glycoprotein (P-gp) inhibitor with IC50 values of 0.42 µM for KB cells and 0.43 µM for MDR KBvin cells. P-gp-IN-31 can pass P-gp-mediated drug efflux mechanisms and shows collateral sensitivity via P-gp downregulation. P-gp-IN-31 inhibits cell proliferation, induces apoptosis and arrests the cell cycle at G2/M phase. P-gp-IN-31 can be used for the research of cancer, such as multidrug-resistant (MDR) malignancies[1].
Molecular Weight:
303.26
Formula:
C16H11F2NO3
Target:
Apoptosis,P-glycoprotein
Application Notes:
MCE Product type: Reference compound
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