MS44 is a potent aurora kinase B (AURKB PROTAC) degrader (DC50 = 103 nM). MS44 effectively degrades AURKB in a time- and ubiquitin-proteasome system (UPS)-dependent manner and is selective for AURKB over AURKA and AURKC. MS44 effectively inhibits the proliferation in multiple cancer cell lines and potently induces G2/M arrest. MS44 can be used for the study of AURKB-dependent tumors (Pink: Target protein ligand (HY-175526), Blue: E3 ligand (HY-112078), Black: Linker, E3 ligand + Linker (HY-132938))[1].
Molecular Weight:
1090.31
Formula:
C57H72FN11O8S
Target:
Aurora Kinase,PROTACs
Application Notes:
MCE Product type: Reference compound
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