EGFR-IN-169 is an epidermal growth factor (EGFR) (IC50 = 5.19 µM) inhibitor form panaxadiol. EGFR-IN-169 interferes with the migration and growth of colorectal cancer cells by inhibiting EGFR-mediated RalA/EMT pathway. EGFR-IN-169 shows an IC50 value of 4.46 µM and SI of 16.92 for HCT-116 cells. EGFR-IN-169 inhibits CDKs activity, induces G0/G1 cycle arrest and inhibits migration and invasion. EGFR-IN-169 reduces mitochondrial membrane potential and induces apoptosis and ROS production. EGFR-IN-169 can be used for the research of cancer, such as colorectal cancer[1].
Molecular Weight:
682.33
Formula:
C40H56ClNO6
Target:
Apoptosis,Bcl-2 Family,CDK,EGFR,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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