USP10-IN-4 is a potent ubiquitin-specific protease 10 (USP10) inhibitor with an IC50 of 10.87 µM and a Kd of 365 nM. USP10-IN-4 effectively inhibits USP10-mediated proteasomal degradation of downstream proteins YAP and p53, leading to the subsequent downregulation of CDK4 in the p53 signaling pathway. USP10-IN-4 promotes apoptosis in HCC cells and inhibits the onset and progression of liver cancer. USP10-IN-4 can used for the study of hepatocellular carcinoma (HCC)[1].
Molecular Weight:
487.98
Formula:
C28H26ClN3O3
Target:
Apoptosis,CDK,Deubiquitinase,MDM-2/p53,YAP
Application Notes:
MCE Product type: Reference compound
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