KB-15 is a STAT3 inhibitor. KB-15 exhibits potent anti-proliferative activity against AGS gastric cancer cells (IC50 = 0.29 µM) and BGC-823 gastric cancer cells (IC50 = 0.65 µM). KB-15 exerts anti-tumor effects by inhibiting STAT3 phosphorylation, downregulating HO-1 expression, and promoting intracellular ROS accumulation. KB-15 induces G0/G1 phase cell cycle arrest and apoptosis, as well as suppresses colony formation and migration of gastric cancer cells. KB-15 demonstrates excellent anti-tumor efficacy in BGC-823 subcutaneous xenograft model. KB-15 can be used for the study of gastric cancer[1].
Molecular Weight:
430.11
Formula:
C18H12Cl4N2O2
Target:
Apoptosis,PARP,Reactive Oxygen Species (ROS),STAT
Application Notes:
MCE Product type: Reference compound
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