MMP-9-IN-12 is a matrix metalloproteinase-9 (MMP-9) inhibitor with an IC50 of 6.57 µM. MMP-9-IN-12 shows an IC50 value of 1.54 µM for HCT-116 cells. MMP-9-IN-12 induces cell apoptosis, ROS production and mitochondrial depolarization. MMP-9-IN-12 inhibits cells migration and disrupts cell cycle progression. MMP-9-IN-12 can be used for the research of colorectal cancer (CRC)[1].
Molecular Weight:
517.96
Formula:
C28H24ClN3O5
Target:
Apoptosis,MMP,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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