Photosensitizer-7 is a endoplasmic reticulum (ER)-targeted photosensitizer (PS) (lambdaab = 610 nm, lambdaem = 622 nm). Photosensitizer-7shows an IC50 of 4.006 µM in HeLa cells and 3.28 µM in MCF-7 cells under light irradiation. Photosensitizer-7 exhibits dose-dependent cellular uptake and predominant colocalization with ER. Photosensitizer-7 induces dose-dependent intracellular ROS generation, reduces mitochondrial membrane potential, and increases apoptosis upon light irradiation in cells. Photosensitizer-7 significantly inhibits tumor growth in MCF-7 tumor-bearing mice. Photosensitizer-7 can be used for the study of photodynamic anticancer applications[1].
Molecular Weight:
700.57
Formula:
C43H37BF4N2O2
Target:
Apoptosis,Photosensitizer,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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