M6766 is a selective endoplasmic reticulum oxidoreductase 1alpha (ERO1alpha) inhibitor with an IC50 of 1.4 µM and a KD of 1.1 µM. M6766 also inhibits ERO1beta with an IC50 of 7.2 µM. M6766 binds to the flavin adenine dinucleotide-binding pocket in ERO1alpha. M6766 inhibits granule secretion, alphaIIbbeta3 integrin activation, Ca2+ mobilization, and platelet aggregation. M6766 can be used for the research of neurological disease, such as ischemic stroke[1].
Molecular Weight:
360.44
CAS Number:
[696628-90-7]
Formula:
C19H16N6S
Target:
Endoplasmic Reticulum Oxidoreductase 1 (ERO1),Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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