NLRP3/URAT1-IN-1, CAS [[2994637-53-3]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-175645
Supplier Catalog Number:
HY-175645
Alternative Catalog Number:
MCE-HY-175645-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
NLRP3/URAT1-IN-1 is an orally active double inhibitor of NLRP3 and URAT1 (IC50 = 3.81 µM). NLRP3/URAT1-IN-1 inhibits IL-1beta release in LPS (HY-D1056) and ATP-stimulated mouse bone marrow-derived macrophages (BMDMs), with an IC50 of 2.61 µM. NLRP3/URAT1-IN-1 reduces serum uric acid (SUA) and alleviates liver/kidney damage in mice with acute hyperuricemia (HUA). NLRP3/URAT1-IN-1can be used for the study of gout and hyperuricemia[1].
