NNRT-IN-12 (compound 19) is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor with an IC50 value of 0.107 µM for WT HIV-1 RT. NNRT-IN-12 shows anti-HIV-1 activity with EC50 value of 14.1, 5.03, 7.64, 27.1 nM for L100I, K103N, Y181C, Y188L mutant HIV-1 strains, respectively. NNRT-IN-12 shows cytotoxicity[1].
Molecular Weight:
574.64
Formula:
C30H28F2N6O2S
Target:
HIV,Reverse Transcriptase
Application Notes:
MCE Product type: Reference compound
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