GABAA receptor modulator-10 is an orally active, potent positive allosteric modulator (PAM) of the alpha1beta2gamma2 GABAA receptor with favorable blood-brain barrier (BBB) penetration. GABAA receptor modulator-10 enhances alpha1beta2gamma2 GABAA receptor function and potentiates GABA-evoked currents. GABAA receptor modulator-10 demonstrates potent antiepileptic efficacy in both the Pentetrazol (PTZ)- and Kainic Acid (KA) (HY-N2309)-induced mice epilepsy models. GABAA receptor modulator-10 can be used for the study of epilepsy[1].
Molecular Weight:
395.82
Formula:
C20H15ClFN5O
Target:
GABA Receptor
Application Notes:
MCE Product type: Reference compound
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