MRGPRX4 modulator-3 (Compound 1C) is a negative allosteric MAS-related G-protein-coupled receptor X4 (MRGPRX4) modulator. MRGPRX4 modulator-3 significantly attenuates Nateglinide (HY-B0422) (orthosteric agonist)-induced responses with an IC50 of 337 nM. MRGPRX4 modulator-3 can be used for chronic itch (especially cholestatic itch) and pain research[1].
Molecular Weight:
343.46
Formula:
C19H22FN3S
Target:
Mas-related G-protein-coupled Receptor (MRGPR)
Application Notes:
MCE Product type: Reference compound
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