MOMA-341 is a selective Werner RecQ like helicase (WRN) inhibitor. MOMA-341 binds to WRN at cysteine 727 through an allosteric and ATP-competitive binding mechanism. MOMA-341 induces DNA damage, cell death, and tumor regressions in mismatch-repair deficient (dMMR)/microsatellite instability high (MSI-H) mice model. MOMA-341 has antitumor activity, promising for advanced and metastatic solid tumors research[1].
Molecular Weight:
570.54
CAS Number:
[3078276-74-8]
Formula:
C28H26F4N6O3
Target:
DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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