EN1033 is a covalent immune regulatory transcription factor 5/8 (IRF5/8) molecular glue degrader. EN1033 degrades IRF5 in a proteasome-dependent manner. EN1033 engages and degrades IRF8 more robustly and rapidly. EN1033 covalently targets C28 and C223 to destabilize and degrade IRF5 and IRF8 respectively, thereby inhibiting their pro-inflammatory transcriptional activity. EN1033 serves as a promising tool for the study of autoimmune and inflammatory disorders[1].
Molecular Weight:
242.32
Purity:
99.96
CAS Number:
[2193367-28-9]
Formula:
C15H18N2O
Target:
IFNAR,Molecular Glues
Application Notes:
MCE Product type: Reference compound
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