STAT3-IN-46 is a selective and orally active inhibitor of signal transducer and activator of transcription 3 (STAT3) (KD = 323.3 nM). STAT3-IN-46 directly binds to the SH2 domain of the STAT3 and inhibits IL-6/JAK/STAT3 signaling pathway (IC50 = 0.87 µM) and downregulates c-Myc and Bcl-2 levels. STAT3-IN-46 can be used for the research of cancer, such as triple-negative breast cancer[1].
Molecular Weight:
564.68
Formula:
C31H29FN8S
Target:
Bcl-2 Family,c-Myc,Interleukin Related,JAK,STAT
Application Notes:
MCE Product type: Reference compound
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