CD28-IN-1 (Compound 19MS-5) is a CD28 inhibitor with a KD of 12.48 µM. CD28-IN-1 has a superior binding capacity to CD28 and potently inhibits CD28-B7 interactions. CD28-IN-1 inhibits CD28-driven immune activation and suppresses cytokine (IFN-gamma, IL-2 and TNF-alpha) production in primary human T cells co-cultured with tumor spheroids and human epithelial tissues. CD28-IN-1 can be used for tumor immunity research[1].
Molecular Weight:
315.32
CAS Number:
[1465291-19-3]
Formula:
C16H17N3O4
Target:
CD28,IFNAR,Interleukin Related,TNF Receptor
Application Notes:
MCE Product type: Reference compound
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