APJ antagonist-1 is an apelin receptor (APJ) antagonist. APJ antagonist-1 shows strong beta-arrestin inhibition with an IC50 of 3.1 µM. APJ antagonist-1 selectively inhibits APJ-overexpressing cancer cells and suppresses apelin-induced endothelial cell migration. APJ antagonist-1exhibits high metabolic stability. APJ antagonist-1 can used for the studies of ovarian cancer and tumor angiogenesis[1].
Molecular Weight:
433.46
Formula:
C18H15N3O6S2
Target:
Apelin Receptor (APJ)
Application Notes:
MCE Product type: Reference compound
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