CDK2 degrader 7 is an orally active CDK2 degrader, with DC50 values of 13 nM (MKN1cells) and 17 nM (TOV21G cells). CDK2 degrader 7 induces G1 phase arrest in MKN1 cells. CDK2 degrader 7 achieves tumor stasis in HCC1569 (CCNE1-amplified) xenograft models. CDK2 degrader 7 can be used for the study of CCNE1-amplified cancers[1].
Molecular Weight:
852.89
CAS Number:
[3030279-55-8]
Formula:
C39H46F6N8O5S
Target:
CDK
Application Notes:
MCE Product type: Reference compound1
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