CAI/II-IN-12 is a potent and hCAI (IC50 = 7.12 µM, Ki = 9.26 µM) and hCAII (IC50 = 10.62 µM, Ki = 11.72 µM) dual inhibitor. CAI/II-IN-12 has a strong affinity for the active sites of CYP17A1, hCAI, and hCAII enzymes. Compound CAI/II-IN-12 exhibits rapid conformational stabilization, particularly in the CYP17A1 complex. CAI/II-IN-12 can be used for the study of prostate cancer therapy and glaucoma[1].
Molecular Weight:
504.56
Formula:
C26H24N4O5S
Target:
Carbonic Anhydrase
Application Notes:
MCE Product type: Reference compound1
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