TEC 4 is a ByeTAC (Bypassing E-Ligase-Targeting Chimera) BRD4 degrader, with 33% BRD4 remaining at 500 nM in Ramos B-cells. TEC 4 shows toxicity for Ramos B-cells, with an IC50 of 30.5 nM. ByeTACs directly recruits a protein to the proteasome via interactions with Rpn-13 for degradation. Pink: BRD4 lignad (HY-78695), Blue: Rpn-13 ligand (HY-159808), Black: linker (HY-W008352)[1].
Molecular Weight:
1078.92
Formula:
C48H51BrCl2N10O6S2
Target:
ByeTAC,Epigenetic Reader Domain
Application Notes:
MCE Product type: Reference compound
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