Tubulin polymerization-IN-79 (Compound C20) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-79 shows potent antiproliferative activity against esophageal cancer cells (e.g., KYSE450, IC50=0.36 µM, EC-109, IC50=0.63 µM). Tubulin polymerization-IN-79 occupies the colchicine binding site to disrupt microtubule network integrity, activating the Hippo signaling pathway, downregulating the oncogenic protein YAP expression, and inducing G2/M phase arrest and apoptosis in esophageal cancer cells. Tubulin polymerization-IN-79 is promising for research of esophageal cancers[1].
Molecular Weight:
385.39
Formula:
C19H15NO6S
Target:
Apoptosis,Hippo (MST),Microtubule/Tubulin,YAP
Application Notes:
MCE Product type: Reference compound1
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