Tegoprazan (CJ-12420, RQ-00000004), a potassium-competitive acid blocker, is a reversible, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC50 values ranging from 0.29-0.52 µM for porcine, canine, and human H+/K+-ATPases in vitro. Tegoprazan significantly improves colitis in mice and enhances the intestinal epithelial barrier function. Tegoprazan is promising for research of Inflammatory bowel, gastric acid-related, motilityimpaired diseases[1][2][3].
Molecular Weight:
393.42
Formula:
C20H13D6F2N3O3
Target:
Na+/K+ ATPase,Proton Pump
Application Notes:
MCE Product type: Isotope-Labeled Compounds
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