Framycetin (Neomycin B), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a Ki of 35 µM. Framycetin competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin inhibits hammerhead ribozyme with a Ki of 13.5 µM. Framycetin, a 5''-azido neomycin B precursor, binds the Drosha site in miR-525 and is used for hepatic encephalopathy and enteropathogenic E. coli infections[1][2].
Molecular Weight:
614.64
CAS Number:
[119-04-0]
Formula:
C23H46N6O13
Target:
Antibiotic,Bacterial
Application Notes:
MCE Product type: Reference compound1
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