Framycetin sulfate (Neomycin B sulfate), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a Ki of 35 µM. Framycetin sulfate competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin sulfate inhibits hammerhead ribozyme with a Ki of 13.5 µM. Framycetin sulfate, a 5''-azido neomycin B precursor, binds the Drosha site in miR-525 and is used for hepatic encephalopathy and enteropathogenic E. coli infections[1][2].
Molecular Weight:
908.88
Purity:
98
CAS Number:
[4146-30-9]
Formula:
C23H52N6O25S3
Target:
Antibiotic,Bacterial
Application Notes:
MCE Product type: Reference compound
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